Health is our most valuable asset. bitop offers you safe and IP-protected medical devices with clinically proven efficacy.

Most of the common ailments today – e.g. cough and cold, allergies, eczema, dry eyes – and even more severe conditions such as mucositis, COPD, or asthma are caused by disturbed epithelia or by an unstable skin barrier. These diseases are self-enforcing if the epithelia are not stabilized.

Our Ectoin®-containing medical devices target the stabilization of epithelia as well as the skin barrier. Based on this effect, the products reduce inflammation and alleviate well-known symptoms effectively and naturally. Due to their excellent safety profile they can be used for treatment of patients of all ages, from infants to the elderly.

Maintaining and enhancing wellbeing is our primary goal. Nobody wants to suffer from coughs and colds in winter or be bothered by allergies or eczema. Our Ectoin®-containing products are well suited to help prevent and alleviate the symptoms of such diseases. Taken preventively, the products stabilize the mucosa in such a way that germs or allergens have difficulty entering and harming the body. On the skin, the time between eczema attacks can be prolonged when the creams are used steadily. Since our products do not contain any ingredients that harm the body, they can be used continuously to improve your health and wellbeing.

Another outstanding feature of our healthcare products is their IP protection for the most important global markets as well as their scientifically proven efficacy.


Dermatology


Ectoin® Dermatitis Cream 7%

Effective and natural treatment of inflammatory dermatoses without negative side effects

Claims

Cream for the symptomatic treatment and relief of skin redness and itching experienced with various types of inflammatory dermatoses.

  • Helps to relieve and calm irritated and damaged skin by reducing inflammatory reactions and supporting the regeneration process
  • Pro-active treatment of atopic dermatitis in the sub-acute state due to skin barrier stabilizing and protective properties
  • Reduces dryness by increasing skin moisture content and therefore smooths the skin
  • Soothes symptoms like itchiness and redness

Ingredients

Ectoin®, Aqua, Hydrogenated Lecithin, Ceramide-3, Squalane, Olea Europaea Fruit Oil, Caprylic/Capric Triglyceride, Butyrospermum Parkii Butter, Oryza Sativa (Rice) Bran Cera, Carbomer, Xanthan Gum, Sodium Carbomer, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Glycine, Alanine, Pentylene Glycol, Butylene Glycol, Hydroxyethylcellulose, Glycerine, Hydroxyphenyl Propamidobenzoic Acid.

Suitable for

Infants, children and adults

Dosage Forms

  • Airless Dispenser (30 ml, 50 ml)
  • Aluminium Tube (30 ml, 50 ml)
  • Sachet (2 ml, 3 ml, 5 ml)

Study Overview

Marini et al., 2013; Heinrich et al., 2007;
Bünger and Driller, 2004

  • Strong scientific background: More than 15 studies with diverse Ectoin®-containing creams including >900 patients prove outstanding efficacy and safety of Ectoin®-containing creams
  • Tested against Atopiclair® and Hydrocortisone-containing cream
  • Efficient reduction of itching, erythema and irritation

Status (EU): Medical Device Class IIa


Ectoin® Dermatitis Cream 3,5%

More than just basis therapy of dermatitis

Claims

Cream for topical use on dry, irritated and sensitive skin associated with various types of dermatoses.

  • Can be used between exacerbations to stabilize the skin barrier and protect the skin against external stress factors
  • Supports the regeneration process
  • Soothes dry, rough and sensitive skin
  • Provides moisture and protects against dehydration

Ingredients

Aqua, Ectoin®, Hydrogenated Olive Oil, Ethylhexyl Stearate, Pentylene Glycol, Simmondsia Chinensis Seed Oil, Sorbitol, Cetearyl Alcohol, Polyglyceryl-2 Sesquiisostearate, Hexyldecanol, Hexyldecyl Laurate, Ethylhexylglycerin, Hydrogenated Vegetable Glycerides, Sodium Cocoyl Glutamate, Sodium Carbomer, Tocopheryl Acetate, Prunus Amygdalus Dulcis Oil, Citrus Tangerina Peel Oil, Hydrogenated Vegetable Oil, Tocopherol, Hydrogenated Palm Glycerides Citrate.

Suitable for

Infants, children and adults

Dosage Forms

  • Airless Dispenser (30 ml, 50 ml)
  • Aluminium Tube (30 ml, 50 ml)
  • Sachet (2 ml, 3 ml, 5 ml)

Study Overview

  • Strong scientific background: More than 15 studies with diverse Ectoin®-containing creams including >900 patients prove outstanding efficacy and safety of Ectoin®-containing creams.

Status (EU): Medical Device Class IIa


Ectoin® Psoriasis Cream

Supports elimination of plaque, reduces itching, scaling and redness

Psoriasis Cream

Claims

Cream for treatment and prevention of psoriasis symptoms

  • Supports the natural elimination of dead cells from the skin surface which is a symptom of psoriasis
  • Reduces scaling, itching, redness, roughness and hardening of the skin
  • Helps to normalize skin cell production and maturation time of the skin
  • Stabilizes the skin barrier
  • Moisturizes the skin and prevents further dehydration

Ingredients

Ectoin®, Aqua, Cetearyl Alcohol, Urea, Cetearyl Isononanoate, Glycerin, Simmondsia Chinensis Seed Oil, Hydrogenated Polydecene, Pentylene Glycol, Hydroxyethyl Urea, Panthenol, Cetearyl Glucoside, Lecithin, Allantoin, Xanthan Gum, Ethylhexylglycerin, Sodium Lactate, Sodium Cetearyl Sulfate, Triacetin.

Suitable for

Infants, children and adults

Dosage Forms

  • Aluminium Tube (30 ml, 50 ml)

Study Overview

Vestweber, 2009

  • Post-marketing surveillance study proves: Great improvement of scaliness, dryness and pruritus.

Status (EU): Medical Device Class IIa


Ectoin® Scalp Tonic

Itch and dandruff reduction for irritated scalp

Claims

Scalp Tonic for the treatment of itchy and dry scalp

  • Soothes itchiness
  • Strengthens the skin-barrier function which results in e.g. reduced pollen allergen penetration into hair follicles
  • Helps to protect hair follicles from aging which is a cause for reduced hair thickness, hair density and greying
  • Reduces inflammatory reactions of the scalp
  • Supports the regeneration process of the irritated scalp
  • Reduces symptoms like dryness of the scalp
  • Leaves the hair clean, is neither greasy nor heavy

Ingredients

Single-dose: Ectoin®, Sea Salt, Water
Multi-dose: Ectoin®, Sea Salt, Phenoxyethanol, Limonene, Water.

Suitable for

Infants, children and adults

Dosage Forms

2.5 ml solution in single-dose units (preservative-free) or multi-dose bottle with nozzle (100 ml solution)

Study Overview

  • Observational study shows significant improvement of dryness, redness, dandruff, and irritation after only 2 weeks.

Status (EU): Medical Device Class I


Allergy


Ectoin® Allergy Nasal Spray 2%

The innovation for treatment and prevention of allergic rhinitis symptoms

Claims

Nasal Spray for treatment and prevention of allergic rhinitis symptoms.

  • Reduces allergen induced inflammations of the nasal mucosa
  • Alleviates allergic symptoms (itchy and runny nose, sneezing, nasal congestion)
  • Supports the regeneration process of irritated nasal mucosa caused by allergens
  • Reduces harmful influences of allergens and airborne particles, also suitable for the preventive use

Ingredients

Ectoin®, Sea Salt, Water.

Suitable for

Infants, children and adults

Dosage Forms

e.g. 20 ml solution in bottle with dosage pump

Study Overview

Werkhäuser et. al., 2014; Sonnemann et. al., 2014;
Eichel et. al., 2014; Abdulkerimov et al., 2016;
Minaeva et al., 2015

  • Tested against standard OTC drugs and placebo: As effective as cromoglicic acid, beclometasone or azelastine-containing nasal sprays
  • Seven studies including nearly 400 patients show: significant improvement of local symptoms and excellent safety profile

Status (EU): Medical Device Class I


Ectoin® Allergy Eye Drops 2%

The innovation for treatment and prevention of allergic conjunctivitis symptoms

Claims

Eye Drops for treatment and prevention of allergic conjunctivitis symptoms.

  • Reduce allergen induced inflammation of the conjunctiva
  • Alleviate allergic symptoms (red, itchy and watery eyes)
  • Protect against the harmful influences of allergens
  • Support the regeneration process of irritated and sensitive conjunctiva

Ingredients

Ectoin®, Sodium Chloride, Hydroxyethyl Cellulose, Citrate Buffer, Water.

Suitable for

newborn, infants, children and adults

Dosage Forms

0.5 ml solution in ampoules or 10 ml in multi-dose dropper (OSD or 3K®)

Study Overview

Salapatek et al., 2011; Werkhäuser et. al., 2014; Skrypnyk 2015; Allegri et. al., 2014; Drozhzhina and Troichenko, 2015;

  • Diverse studies show significant reduction of local symptoms during allergic conjunctivitis Tested against standard OTC drugs and placebo: as effective as Azelastine and Ketotifen-containing eye drops
  • Excellent tolerability and safety proven in children and adults

Status (EU): Medical Device Class Is


Ectoin® Nasal Douche

Symptom reduction and cleansing during allergic rhinitis and common cold

Claims

Nasal douche for prevention and treatment of rhinitis and rhinosinusitis symptoms

  • Reduces inflammations of disturbed mucosa in the nose
  • Alleviates symptoms such as dry and sore nasal mucosa, sneezing, itching, congestion, and crust formation
  • Reduces harmful influences of allergens and airborne particles
  • Supports the regeneration process of irritated nasal mucosa
  • Gently cleans nasal cavities
  • Provides essential moisture and prevents dehydration
  • Helps to naturally decongest the nasal mucosa

Ingredients

Ectoin®, Sea Water, purified Water.

Suitable for

Children and adults

Dosage Forms

50 ml, 100 ml or 125 ml solution in a Bag-On-Valve system

Status (EU): Medical Device Class I


Ectoin® Mouth & Throat Spray 1%

Treatment and prevention of sore throat

Claims

Mouth and throat spray for treatment and prevention of dry and irritated epithelia in mouth and throat

  • Helps to relieve sore throat, hoarseness, cough, and pain on swallowing
  • Supports reduction in inflammation of the mucous membranes in mouth and throat
  • Prevents irritation of mucous membranes caused by cold air or air conditioning
  • Soothes itchy palate caused by allergies
  • Supports regeneration of dry and irritated membranes

Ingredients

Ectoin®, Sea Salt, Phosphate Buffer, Mint Oil, Xylitol, Water.

Suitable for

Children older than two years and adults

Dosage Forms

20 ml bottle with dosage pump

Study Overview

Müller et al., 2016

  • Tested against mineral salt pastilles: Superior efficacy in treating acute pharyngitis and/or laryngitis compared to “Emser® Pastillen”

Status (EU): Medical Device Class I


Ectoin® Mouth & Throat Spray + CA/XY

New generation of sore throat treatment

Claims

Mouth and throat spray for treatment and prevention of dry and irritated epithelia in mouth and throat

  • Reduces sore throat, hoarseness, cough, and pain on swallowing
  • Helps to reduce the duration of a sore throat/hoarseness by reduction of bacterial ingression due to the modified Ectoin® Hydro Complex and the stabilized mucosal barrier structure
  • Reduces allergen ingression and therefore soothes buccal symptoms caused by pollen allergies
  • Supports reduction in inflammation of the mucous membranes in mouth and throat

Ingredients

Ectoin®, Sea Salt, Phosphate Buffer, Xylitol, Sodium Cyclamate, Caprylic Acid, Mint Oil, Salvia Oil, Water.

Suitable for

Children older than two years and adults

Dosage Forms

20 ml bottle with dosage pump

Study Overview

Müller et al., 2016

  • Superior efficacy in treating acute pharyngitis and/or laryngitis compared to mineral salt pastilles (Emser® Pastillen) was shown with another Ectoin®-containing mouth and throat spray formulation.

Status (EU): Medical Device Class I


Ectoin® Inhalation Solution

Effective bronchitis treatment and symptom reduction in asthma and COPD

Claims

Inhalation solution for supportive treatment to reduce inflammations of the airways in case of bronchitis, asthma or Chronic Obstructive Pulmonary Disease (COPD)

  • For supportive treatment and symptom alleviation of diseases of the airways, such as allergic or non-allergic asthma, or Chronic Obstructive Pulmonary Disease (COPD)
  • For supportive treatment and prevention of bronchitis symptoms
  • Protects and moisturizes the mucosa of the airways (e. g. when exposed to particulate matter, pollen, dust or dry air in heated or air conditioned rooms)
  • Prevents symptoms of allergic reactions of the respiratory system while suffering from e. g. allergic asthma, house-dust allergy, etc

Ingredients

Ectoin®, Sea Salt, Water.

Suitable for

Newborn, infants, children and adults

Dosage Forms

2.5 ml solution in single-dose units for jet, mesh, or ultrasound nebulizers

Study Overview

Unfried et. al., 2010; Sydlik et. al., 2013; Unfried et. al., 2014; Unfried et. al., 2016

  • Tested in patients with acute infections of the respiratory system, asthma and bronchitis
  • Proven reduction of lung inflammation due to lifelong exposure to environmental air pollution
  • Several preclinical and clinical studies prove significant reduction of inflammation markers after treatment with Ectoin®.

Status (EU): Medical Device Class IIa


Ectoin® Ear Spray

Itch reduction, soothing, and cleaning for sensitive ears

Claims

Ear spray for treatment of symptoms caused by non-infectious inflammation of the outer ear, for prevention of otitis externa and earwax plugs, and for eased clearing of the outer ear canal

  • Alleviates pruritus in the outer ear canal caused by allergy or inflammatory dermatoses
  • Soothes dry skin inside the ear canal
  • Reduces inflammation and supports the regeneration process in non-infectious otitis externa
  • Helps to reduce the incidence of otitis externa, if used regularly
  • Helps against formation of earwax plugs, if used regularly
  • Cleans the ear canal

Ingredients

Ectoin®, Sea Salt, Citrate Buffer and Water.

Suitable for

Infants, children and adults

Dosage Forms

20 ml or 30 ml solution in bottle with dosage pump

Study Overview

  • Tested against Dexpanthenol: Ectoin® Ear Spray shows significantly better improvement of itching, impairment of daily life and scaly skin.
  • No common side effects of other ear sprays (such as temporary burning or stinging) were observed with the Ectoin® Ear Spray.

Status (EU): Medical Device Class I


Cough and Cold


Ectoin® Rhinitis Nasal Spray

Natural treatment and relief of non-allergic rhinitis and rhinosinusitis

Claims

Nasal Spray for treatment and prevention of non-allergic rhinitis or rhinosinusitis symptoms.

  • Reduces inflammations of disturbed nasal mucosa and sinuses caused by rhinitis and rhinosinusitis (common cold)
  • Alleviates typical symptoms such as dry and wounded nasal epithelium, sneezing, itching and crust formation.
  • Decongests the nose and sinuses naturally
  • Supports the reduction in the use of decongestant nasal sprays

Ingredients

Ectoin®, Sea Salt, Phosphate Buffer, Water.

Suitable for

Infants, children and adults

Dosage Forms

20 ml bottle with dosage pump

Study Overview

Eichel et al., 2013

  • Significant reduction of primary symptoms of acute rhinosinusitis
  • Tested against German OTC bestseller: Ectoin® Rhinitis Nasal Spray is as effective as Sinupret® forte.
  • Consumer survey shows: Sensory properties of the Ectoin® Rhinitis Nasal Spray are „very well“.

Status (EU): Medical Device Class I


Ectoin® Nasal Balm

Effective relieve for dry and irritated nasal mucosa and skin surrounding nostrils

Claims

Nasal balm for treatment and prevention of dry and sore nasal mucosa and skin around the nostrils

  • Supports the healing process of sore nasal mucosa and skin around the nostrils
  • Reduces inflammation of nasal mucosa and skin around the nostrils and reduces redness
  • Increases skin elasticity and thereby protects the skin around the nostrils from damage due to extensive use of tissues
  • Relieves itching, burning and crust formation inside the nose
  • Supports free breathing

Ingredients

Ectoin®, Mint and Salvia Oil, Aqua, Hydrogenated Lecithin, Ceramide-3, Squalane, Olea Europaea Fruit Oil, Caprylic/Capric Triglyceride, Butyrospermum Parkii Butter, Oryza Sativa (Rice) Bran Cera, Carbomer, Xanthan Gum, Sodium Carbomer, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Glycine, Alanine, Pentylene Glycol, Butylene Glycol, Hydroxyethylcellulose, Glycerine, Hydroxyphenyl Propamidobenzoic Acid.

Suitable for

Children older than 6 years and adults

Dosage Forms

Aluminum tube, 3 ml or 5 ml

Study Overview

  • Several studies with diverse Ectoin®-containing creams show great efficacy in reduction of redness and stabilization of the skin barrier.

Status (EU): Medical Device Class I
(in process of CE registration)


Ectoin® Mouth & Throat Spray 1%

Treatment and prevention of sore throat

Claims

Mouth and throat spray for treatment and prevention of dry and irritated epithelia in mouth and throat

  • Helps to relieve sore throat, hoarseness, cough, and pain on swallowing
  • Supports reduction in inflammation of the mucous membranes in mouth and throat
  • Prevents irritations of mucous membranes caused by cold air or air conditioning
  • Soothes itchy palate caused by allergies
  • Supports regeneration of dry and irritated membranes

Ingredients

Ectoin®, Sea Salt, Phosphate Buffer, Mint Oil, Xylitol, Water.

Suitable for

Children older than two years and adults

Dosage Forms

20 ml bottle with dosage pump

Study Overview

Müller et al., 2016

  • Tested against mineral salt pastilles: Superior efficacy in treating acute pharyngitis and/or laryngitis compared to “Emser® Pastillen”

Status (EU): Medical Device Class I


Ectoin® Mouth & Throat Spray + CA/XY

New generation of sore throat treatment

Claims

Mouth and throat spray for treatment and prevention of dry and irritated epithelia in mouth and throat

  • Reduces sore throat, hoarseness, cough, and pain on swallowing
  • Helps to reduce the duration of a sore throat/hoarseness by reduction of bacterial ingression due to the modified Ectoin® Hydro Complex and the stabilized mucosal barrier structure
  • Reduces allergen ingression and therefore soothes buccal symptoms caused by pollen allergies
  • Supports reduction in inflammation of the mucous membranes in mouth and throat

Ingredients

Ectoin®, Sea Salt, Phosphate Buffer, Xylitol, Sodium Cyclamate, Caprylic Acid, Mint Oil, Salvia Oil, Water.

Suitable for

Children older than two years and adults

Dosage Forms

20 ml bottle with dosage pump

Study Overview

Müller et al., 2016

  • Superior efficacy in treating acute pharyngitis and/or laryngitis compared to mineral salt pastilles (Emser® Pastillen) was shown with another Ectoin®-containing mouth and throat spray formulation.

Status (EU): Medical Device Class I


Ectoin® Lozenges (Gum Arabic Pastilles)

Protection shield against common cold symptoms, dry mouth and hoarseness

Claims

Lozenges for the treatment and prevention of common cold symptoms, dry mouth and throat, and hoarseness due to voice overuse.

  • Reduces inflammation of the mucous membranes in mouth and throat
  • Helps to relieve hoarseness, sore throat, or pain on swallowing
  • Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infection in the mouth and throat
  • Reduces and prevents irritations of the mucous membranes such as voice fatigue, tickly throat, or dryness
  • Hydrates dry epithelia and supports their regeneration

Ingredients

Ectoin®, Wildberry Flavour, Menthol, Grape Skin Extract, Citric Acid, Acesulfame K, Gum Arabic, Maltitol, Sorbitol, Water, Vegetable Oil and Beeswax.

Suitable for

Children older than 6 years and adults

Dosage Forms

Blister strips containing 10 lozenges à 1 g or 2 g

Study Overview

  • Tested against German bestseller (HA-containing lozenges) and salt water gargling solution
  • Significant improvement of the sum of pharyngitis symptoms (pain on swallowing, tickle in the throat and hoarseness) proven in clinical trial

Status (EU): Medical Device Class I


Ectoin® Lozenges HC (Hard Candies)

Protection shield against common cold symptoms, dry mouth and hoarseness

Claims

Lozenges for the treatment and prevention of common cold symptoms, dry mouth and throat, and hoarseness due to voice overuse

  • Reduces inflammation of the mucous membranes in mouth and throat
  • Relieve hoarseness, sore throat, or pain on swallowing
  • Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infection in the mouth and throat
  • Reduces and prevents irritations of the mucous membranes such as voice fatigue, tickly throat, or dryness
  • Hydrates dry epithelia and supports their regeneration

Ingredients

Ectoin®, Isomalt, Sucralose, Menthol, Citric Acid, Lemon Mint Flavour (containing tocopherol), Honey Flavour (containing polyethylene glycol), Safflor Concentrate, Glucose Syrup, Water.

Suitable for

Children older than 6 years and adults

Dosage Forms

Blister strips containing 10 lozenges à 2.3 g

Study Overview

  • Study with another Ectoin®-containing lozenge show great efficacy in reducing sore throat and other pharyngitis symptoms.

Status (EU): Medical Device Class I


Ectoin® Lozenges HC + Salt

Protection shield against common cold symptoms, dry mouth and hoarseness

Claims

Lozenges for treatment and prevention of common cold symptoms, dry mouth and throat, and hoarseness due to voice overuse.

  • Reduces inflammations of the mucous membranes in mouth and throat.
  • Relieves hoarseness, sore throat, or pain on swallowing and increases saliva production.
  • Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infection in mouth and throat.
  • Reduces and prevents irritations of the mucous membranes such as voice fatigue, tickly throat, or dryness.
  • Dissolves thick and compact mucus which leads to a free feeling in the throat.

Ingredients

Ectoin®, Sea Salt, Isomalt, Sucralose, Honey Flavour (containing glycerol triacetate and propylene glycol), Safflower Concentrate, Water.

Suitable for

Children older than 6 years, adolescents and adults

Dosage Forms

Blister strips containing 8 lozenges à 2.3 g

Study Overview

  • Studies with Ectoin®  Lozenges show great efficacy in reducing sore throat and other pharyngitis symptoms.

Status (EU): Medical Device Class I


Ectoin® Inhalation Solution

Effective bronchitis treatment and symptom reduction in asthma and COPD

Claims

Inhalation solution for supportive treatment to reduce inflammation of the airways in case of bronchitis, asthma or Chronic Obstructive Pulmonary Disease (COPD)

  • For supportive treatment and symptom alleviation of diseases of the airways, such as allergic or non-allergic asthma, or Chronic Obstructive Pulmonary Disease (COPD)
  • For supportive treatment and prevention of bronchitis symptoms
  • Protects and moisturizes the mucosa of the airways (e. g. when exposed to particulate matter, pollen, dust or to dry air in heated or air conditioned rooms)
  • Prevents symptoms of allergic reactions of the respiratory system while suffering from e. g. allergic asthma, house-dust allergy, etc

Ingredients

Ectoin®, Sea Salt, Water.

Suitable for

Newborn, infants, children and adults

Dosage Forms

2.5 ml solution in single-dose units for jet, mesh, or ultrasound nebulizers

Study Overview

Unfried et. al., 2010; Sydlik et. al., 2013; Unfried et. al., 2014; Unfried et. al., 2016

  • Tested in patients with acute infections of the respiratory system, asthma and bronchitis
  • Proven reduction in lung inflammation due to lifelong exposure to environmental air pollution
  • Several preclinical and clinical studies prove significant reduction of inflammation markers after treatment with Ectoin®.

Status (EU): Medical Device Class IIa


Ectoin® Nasal Douche

Symptom reduction and cleansing during allergic rhinitis and common cold

Claims

Nasal douche for prevention and treatment of rhinitis and rhinosinusitis symptoms

  • Reduces inflammations of disturbed mucosa in the nose
  • Alleviates symptoms such as dry and sore nasal mucosa, sneezing, itching, congestion, and crust formation
  • Reduces harmful influences of allergens and airborne particles
  • Supports the regeneration process of irritated nasal mucosa
  • Gently cleans nasal cavities
  • Provides essential moisture and prevents dehydration
  • Helps to naturally decongest the nasal mucosa

Ingredients

Ectoin®, Sea Water, purified Water.

Suitable for

Children and adults

Dosage Forms

50 ml, 100 ml or 125 ml solution in a Bag-On-Valve system

Status (EU): Medical Device Class I


Airway Diseases


Ectoin® Inhalation Solution

Effective bronchitis treatment and symptom reduction in asthma and COPD

Claims

Inhalation solution for supportive treatment to reduce inflammation of the airways in case of bronchitis, asthma or Chronic Obstructive Pulmonary Disease (COPD)

  • For supportive treatment and symptom alleviation of diseases of the airways, such as allergic or non-allergic asthma, or Chronic Obstructive Pulmonary Disease (COPD)
  • For supportive treatment and prevention of bronchitis symptoms
  • Protects and moisturizes the mucosa of the airways (e. g. when exposed to particulate matter, pollen, dust or to dry air in heated or air conditioned rooms)
  • Prevents symptoms of allergic reactions of the respiratory system while suffering from e. g. allergic asthma, house-dust allergy, etc

Ingredients

Ectoin®, Sea Salt, Water.

Suitable for

Newborn, infants, children and adults

Dosage Forms

2.5 ml solution in single-dose units for jet, mesh, or ultrasound nebulizers

Study Overview

Unfried et. al., 2010; Sydlik et. al., 2013; Unfried et. al., 2014; Unfried et. al., 2016

  • Tested in patients with acute infection of the respiratory system, asthma and bronchitis
  • Proven reduction in lung inflammation due to lifelong exposure to environmental air pollution
  • Several preclinical and clinical studies prove significant reduction in inflammation markers after treatment with Ectoin®.

Status (EU): Medical Device Class IIa


Dry Epithelia


Ectoin® Sicca Eye Drops

Protection from hyperosmolar tears

Claims

Eye Drops for treatment and prevention of dry eye symptoms

  • Moisten dry eyes and prevent from further dehydration
  • Reduce inflammation caused by an irritated or dry conjunctiva
  • Alleviate symptoms of dry eyes such as burning, dryness, itching etc.
  • Support the regeneration process of dry and irritated conjunctivas
  • Stabilize the lipid layer of the tear film
  • Protect ocular cells from hyperosmolarity
  • Suitable for sensitive eyes and contact lens wearers

Ingredients

Ectoin®, Hydroxyethyl Cellulose, Sorbitol, Water, and Citrate Buffer.

Suitable for

Newborn, infants, children and adults

Dosage Forms

0.5 ml solution in ampoules or 10 ml in multi-dose dropper (OSD)

Study Overview

Dwivedi et. al., 2014 (1), Dwivedi et. al., 2014 (2)

  • Tested against HA-containing eye drops: Non-inferiority proven
  • Significant improvement of tear-break-up time

Status (EU): Medical Device Class IIa


Ectoin® Sicca Eye Drops + HA 0.2%

Tear film stabilization, itch reduction, and moistening of dry eyes

Claims

Eye Drops for treatment and prevention of dry eye symptoms

  • Moisten dry and irritated eyes
  • Reduce burning and itching
  • Stabilize the lipid layer of the tear film and reduce further dehydration
  • Protect ocular cells from hyperosmolarity
  • Aid cell regeneration
  • Suitable for contact lens wearers

Ingredients

Ectoin®, Sodium Hyaluronate, Sodium Chloride, Water and Citrate Buffer.

Suitable for

Newborn, infants, children and adults

Dosage Forms

0.35 ml solution in ampoules or 10 ml in a multi-dose dropper (3K® or OSD)

Study Overview

Dwivedi et. al., 2014 (1), Dwivedi et. al., 2014 (2)

  • Studies with other Ectoin®-containing formulations show significant improvement of tear-break-up time
  • Several preclinical and clinical studies prove: Ectoin® stabilizes lipid layers and improves membrane fluidity effectively

Status (EU): Medical Device Class IIa


Ectoin® Sicca Nasal Spray

More than just a saline nasal spray: Long-term moisturization and inflammation-reduction

Claims

Nasal Spray for symptomatic treatment and prevention of dry nose syndrome

  • Alleviates typical symptoms of dry nose syndrome (crust formation, itching in the nose)
  • Reduces inflammations caused by disturbed and dry nasal mucosa
  • Provides essential moisture to dry and irritated noses
  • Supports the regeneration process of irritated nasal mucous membranes
  • Gently cleans nasal cavities and is also suitable for preventive use

Ingredients

Ectoin®, Sea Salt, Phosphate Buffer and Water.

Suitable for

Infants, children and adults

Dosage Forms

e.g. 20 ml solution in bottle with dosage pump

Study Overview

Sonnemann et al., 2014

  • Significant improvement in a combined symptom score (nasal breathing obstruction, blood deposits, crust formation, secretion’s viscosity)
  • Excellent safety profile proven in two studies comprising 80 patients

Status (EU): Medical Device Class I


Ectoin® Mouth Wash

Effective reduction of redness and burning

Claims

Mouth wash for treatment and prevention of dry mouth and other symptoms of inflamed oral mucosa

  • Supports reduction of inflammation of oral mucous membranes (oral mucositis or stomatitis)
  • Helps to reduce the incidence of inflamed oral mucosa
  • Alleviates and prevents symptoms such as sore mouth, redness and burning of the oral mucosa
  • Helps to relieve pain in the mouth and therefore eases eating, drinking, and talking
  • Moistens dry mouth and prevents from further dehydration

Ingredients

Single-Dose: Ectoin®, Hydroxyethyl Cellulose, Phosphate Buffer, Xylitol, and Water.
Multi-Dose: Ectoin®, Succinic Acid, Hydroxyethyl Cellulose, Xylitol, Sodium Benzoate, Sorbic Acid, Natural Orange Flavour, Sodium Hydroxide, Water.

Suitable for

Infants, children and adults

Dosage Forms

10, 20 or 30 single-dose units with 5 ml solution (preservative-free) or a multi-dose bottle (190 ml) with measuring cap

Study Overview

  • First individual studies show: Ectoin® Mouth Wash is able to reduce mucositis grade III and IV to grade I or even asymptomatic within 1–3 weeks of treatment.
  • Comparative study against “Caphosol” is currently running.

Status (EU): Medical Device Class I


Ectoin® Lozenges (Gum Arabic Pastilles)

Protection shield against common cold symptoms, dry mouth and hoarseness

Claims

Lozenges for the treatment and prevention of common cold symptoms, dry mouth and throat, and hoarseness due to voice overuse.

  • Reduces inflammation of the mucous membranes in mouth and throat
  • Helps to relieve hoarseness, sore throat, or pain on swallowing
  • Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infection in the mouth and throat
  • Reduces and prevents irritation of the mucous membranes such as voice fatigue, tickly throat, or dryness
  • Hydrates dry epithelia and supports their regeneration

Ingredients

Ectoin®, Wildberry Flavour, Menthol, Grape Skin Extract, Citric Acid, Acesulfame K, Gum Arabic, Maltitol, Sorbitol, Water, Vegetable Oil and Beeswax.

Suitable for

Children older than 6 years and adults

Dosage Forms

Blister strips containing 10 lozenges à 1 g or 2 g

Study Overview

  • Tested against German bestseller (HA-containing lozenges) and salt water gargling solution
  • Significant improvement of the sum of pharyngitis symptoms (pain on swallowing, tickle in the throat and hoarseness) proven in clinical trial

Status (EU): Medical Device Class I


Ectoin® Lozenges HC (Hard Candies)

Protection shield against common cold symptoms, dry mouth and hoarseness

Claims

Lozenges for the treatment and prevention of common cold symptoms, dry mouth and throat, and hoarseness due to voice overuse

  • Reduces inflammation of the mucous membranes in mouth and throat
  • Relieves hoarseness, sore throat, or pain on swallowing
  • Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infection in the mouth and throat
  • Reduces and prevents irritations of the mucous membranes such as voice fatigue, tickly throat, or dryness
  • Hydrates dry epithelia and supports their regeneration

Ingredients

Ectoin®, Isomalt, Sucralose, Menthol, Citric Acid, Lemon Mint Flavour (containing tocopherol), Honey Flavour (containing polyethylene glycol), Safflor Concentrate, Glucose Syrup, Water.

Suitable for

Children older than 6 years and adults

Dosage Forms

Blister strips containing 10 lozenges à 2.3 g

Study Overview

  • Study with another Ectoin®-containing lozenge show great efficacy in reducing sore throat and other pharyngitis symptoms.

Status (EU): Medical Device Class I


Ectoin® Lozenges HC + Salt

Protection shield against common cold symptoms, dry mouth and hoarseness

Claims

Lozenges for treatment and prevention of common cold symptoms, dry mouth and throat, and hoarseness due to voice overuse.

  • Reduces inflammations of the mucous membranes in mouth and throat.
  • Relieves hoarseness, sore throat, or pain on swallowing and increases saliva production.
  • Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infection in mouth and throat.
  • Reduces and prevents irritations of the mucous membranes such as voice fatigue, tickly throat, or dryness.
  • Dissolves thick and compact mucus which leads to a free feeling in the throat.

Ingredients

Ectoin®, Sea Salt, Isomalt, Sucralose, Honey Flavour (containing glycerol triacetate and propylene glycol), Safflower Concentrate, Water.

Suitable for

Children older than 6 years, adolescents and adults

Dosage Forms

Blister strips containing 8 lozenges à 2.3 g

Study Overview

  • Studies with Ectoin®  Lozenges show great efficacy in reducing sore throat and other pharyngitis symptoms.

Status (EU): Medical Device Class I


Supportive Care


Ectoin® Mouth Wash

Effective reduction of redness and burning

Claims

Mouth wash for treatment and prevention of dry mouth and other symptoms of an inflamed oral mucosa

  • Supports reduction in inflammation of oral mucous membranes (oral mucositis or stomatitis)
  • Helps to reduce the incidence of inflamed oral mucosa
  • Alleviates and prevents symptoms such as sore mouth, redness and burning of the oral mucosa
  • Helps to relieve pain in the mouth and therefore eases eating, drinking, and talking
  • Moistens dry mouth and prevents from further dehydration

Ingredients

Single-Dose: Ectoin®, Hydroxyethyl Cellulose, Phosphate Buffer, Xylitol, and Water.
Multi-Dose: Ectoin®, Succinic Acid, Hydroxyethyl Cellulose, Xylitol, Sodium Benzoate, Sorbic Acid, Natural Orange Flavour, Sodium Hydroxide, Water.

Suitable for

Infants, children and adults

Dosage Forms

10, 20 or 30 single-dose units with 5 ml solution (preservative-free) or a multi-dose bottle (190 ml) with measuring cap

Study Overview

  • First individual studies show: Ectoin® Mouth Wash is able to reduce mucositis grade III and IV to grade I or even asymptomatic within 1–3 weeks of treatment.
  • Comparative study against “Caphosol” is currently running.

Status (EU): Medical Device Class I


Ectoin® Dermatitis Cream 7%

Effective and natural treatment of inflammatory dermatoses without negative side effects

Claims

Cream for symptomatic treatment and relief of skin redness and itching experienced with various types of inflammatory dermatoses.

  • Helps to relieve and calm irritated and damaged skin by reducing inflammatory reactions and supporting the regeneration process
  • Reduces dryness by increasing skin moisture content and therefore smooths the skin
  • Soothes symptoms like itchiness and redness

Ingredients

Ectoin®, Aqua, Hydrogenated Lecithin, Ceramide-3, Squalane, Olea Europaea Fruit Oil, Caprylic/Capric Triglyceride, Butyrospermum Parkii Butter, Oryza Sativa (Rice) Bran Cera, Carbomer, Xanthan Gum, Sodium Carbomer, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Glycine, Alanine, Pentylene Glycol, Butylene Glycol, Hydroxyethylcellulose, Glycerine, Hydroxyphenyl Propamidobenzoic Acid.

Suitable for

Infants, children and adults

Dosage Forms

  • Airless Dispenser (30 ml, 50 ml)
  • Aluminium Tube (30 ml, 50 ml)
  • Sachet (2 ml, 3 ml, 5 ml)

Study Overview

Marini et al., 2013, Heinrich et al., 2007

  • Strong scientific background: More than 15 studies with diverse Ectoin®-containing creams including >900 patients prove outstanding efficacy and safety of Ectoin®-containing creams
  • First individual trials show good efficacy in treating GvHD induced skin irritations

Status (EU): Medical Device Class IIa